Spectrophotometric determination of 4,4'-sulphonyldianiline.

Nagaraja, P. and Sunitha, K. R. and Yathirajan, H. S. and Vasantha, R. A. (2003) Spectrophotometric determination of 4,4'-sulphonyldianiline. Indian Journal of Pharmaceutical Sciences, 65 (1, Cop). pp. 82-84. ISSN 0250-474X

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A simple, rapid, and sensitive spectrophotometric method for the detn. of 4,4'-sulfonyldianiline (dapsone) is described. The method is based on the formation of orange red colored product by the diazotization of dapsone followed by complexation with dopamine in presence of molybdate ions in 1:1 sulfuric acid medium. The product is stable for 2 days at 27°. Beer's law is obeyed in the concn. range of 0.1-8.0 μg/mL at 510 nm. The method is successfully employed for the detn. of dapsone in tablets and common excipients used as additives in pharmaceuticals do not interfere. The method offers the advantages of simplicity, rapidity, and sensitivity without the need for extn. or heating. Limit of detection and limit of quantification are reported. [on SciFinder(R)]

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2003/// [EPrints field already has value set] JA - Indian J. Pharm. Sci. [Field not mapped to EPrints]
Uncontrolled Keywords: dapsone spectrophotometry
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Chandrappa
Date Deposited: 05 Jun 2013 11:25
Last Modified: 05 Jun 2013 11:25
URI: http://eprints.uni-mysore.ac.in/id/eprint/11089

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