3-Aminophenol as a novel coupling agent for the spectrophotometric determination of sulfonamide derivatives.

Nagaraja, P. and Yathirajan, H. S. and Raju, C. R. and Vasantha, R. A. and Nagendra, P. and Hemantha Kumar, M. S. (2003) 3-Aminophenol as a novel coupling agent for the spectrophotometric determination of sulfonamide derivatives. Farmaco, 58 (12, Co). pp. 1295-1300. ISSN 0014-827X

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Official URL: http://dx.doi.org/10.1016/S0014-827X(03)00093-4

Abstract

A rapid, simple and sensitive spectrophotometric method for the detn. of some sulfa drugs is described. The method is based on the formation of orange yellow colored azo product by the diazotization of sulfonamides, viz., dapsone (DAP), sulfathiazole (SFT), sulfadiazine (SFD), sulfacetamide (SFA), sulfamethoxazole (SFMx), sulfamerazine (SFMr), sulfaguanidine (SFG) and sulfadimidine (SFDd) followed by a coupling reaction with 3-aminophenol in aq. medium. Absorbance of the resulting orange yellow product is measured at 460 nm and is stable for 6 days at 27 °C. Beer's law is obeyed in the concn. range of 0.05-8.0 μg/mL at the wavelength of max. absorption. The method is successfully employed for the detn. of sulfonamides in various pharmaceutical prepns. and common excipients used as additives in pharmaceuticals do not interfere in the proposed method. Plausible reaction mechanism is proposed for the formation of the azo product. [on SciFinder(R)]

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2003/// [EPrints field already has value set] M3 - 10.1016/S0014-827X(03)00093-4 [Field not mapped to EPrints] JA - Farmaco [Field not mapped to EPrints]
Uncontrolled Keywords: sulfonamide detn spectroscopy aminophenol
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Chandrappa
Date Deposited: 11 Jun 2013 05:48
Last Modified: 29 Aug 2013 12:04
URI: http://eprints.uni-mysore.ac.in/id/eprint/11015

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