Two phase titration and bromatometric assay of penavarium bromide

Amruthraj, A. K. and Venkatesha, B. M. and Ananda, S. (2013) Two phase titration and bromatometric assay of penavarium bromide. International Journal of Basic and Applied Chemical Sciences, 3 (3). pp. 44-48. ISSN 2277-2073

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Two titrimetric methods for the determination of penavarium bromide (PNB) have been proposed. Based on the quaternary ammonium moiety present in PNB, a titrimetric method (method A) based on ion association complex formation with sodium lauryl sulphate (SLS) as titrant and dimethyl yellow as indicator has been proposed. In another method (method B), a stiochiometric reaction between penavarium bromide and in situ generated bromine has been used in a back titrimetric approach. The methods are applicable over the concentration range 2.0�15 mg and 1.0�10.0 mg for method A and method B, respecttively. Calculations are based on 1:1 molar ratio, i.e., PNB: SLS for method A and PNB: Br2 for method B. Method A is applicable to the determination of PNB in bulk drug and tablet, whereas method B is only applicable to bulk drug due to the interferences from tablet excipients because of non-specifiic reaction of bromine. The methods are validated for accuracy and precision.

Item Type: Article
Uncontrolled Keywords: Two-Phase Titration and Bromination and Bulk Drug
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 31 Dec 2019 06:15
Last Modified: 31 Dec 2019 06:15

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