Synthesis, characterization and antibacterial activity of new triphenyl gathered dihydro pyrazoles

Umesha, B. and Basavaraju, Y. B. (2013) Synthesis, characterization and antibacterial activity of new triphenyl gathered dihydro pyrazoles. International Journal of Chemical and Pharmaceutical Sciences, 4 (4). pp. 33-38. ISSN 0976-9390

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Abstract

New triphenyl gathered pyrazoles were synthesized in two-step reaction via chalcone route. The first step is the synthesis of chalcones by the reaction of acetophenone and substituted aromatic aldehydes in the presence of sodium hydroxide in water-ethanol mixture. The second step is the reaction of chalcones and phenyl hydrazine in absolute alcohol gave triphenyl gathered pyrazoles (3a-h). The synthesized compounds were screened for their antibacterial activity. It is noteworthy that compounds 3a and 3h possessed dominant antibacterial capacity than standard because of presence of p-thiomethyl and p-nitro moiety on 5-substituted phenyl ring at para position against E. coli and S. aureus respectively. The structure of the synthesized triphenyl gathered pyrazoles (3a-h) were confirmed by spectral and elemental analysis data.

Item Type:	Article
Uncontrolled Keywords:	Acetophenone and Aromatic Aldehydes and Chalcones and Phenyl Hydrazine and Triphenyl Gathered Pyrazole Derivatives and Antibacterial Activity
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	20 Dec 2019 11:28
Last Modified:	20 Dec 2019 11:28
URI:	http://eprints.uni-mysore.ac.in/id/eprint/10294

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