Role of pesticides in the nnduction of tumor angiogenesis

Bharathi P. Salimath and Raj, H. M. and Smita Jain and Banerjee, B. D. and Ahmed, T. and Arora, V. K. (2013) Role of pesticides in the nnduction of tumor angiogenesis. Anticancer Research, 33 (1). pp. 231-240.

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Official URL: http://ar.iiarjournals.org/content/33/1/231.short

Abstract

Due to their estrogen-mimicking ability, pesticides are considered as prime etiological suspects of increasing tumor incidence, although a direct link is still undefined. The present study aimed to identify the effect of xenoestrogens (lindane, propoxur and endosulfan) at 20 mg/l each on tumorigenesis, by evaluating endothelial cell proliferation, H-3 thymidine incorporation, wound healing, ascites formation and secretion, shell less Chorio Allantoic Membrane (CAM) formation using in vitro, as well as in vivo, models. The genotoxic effect of xenoestrogens in terms of DNA damage was also studied. The results showed that the endothelial cell proliferation, H-3 thymidine incorporation, wound healing, CAM formation were increased following xenoestrogen exposure, but the intensity of angiogenesis was dependent on the structural homology of these xenoestrogens to endogenous estrogen. Moreover, lindane was the most potent angiogenesis stimulator followed by propoxur and Endosulfan. Further studies were undertaken to examine lindane for its possible carcinogenicity. However, no effect was observed on the integrity of DNA after exposure to these xenoestrogens.

Item Type: Article
Uncontrolled Keywords: Pesticides; cancer; angiogenesis; xenoestrogen
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: Arshiya Kousar
Date Deposited: 13 Dec 2019 06:08
Last Modified: 13 Dec 2019 06:18
URI: http://eprints.uni-mysore.ac.in/id/eprint/10192

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